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Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Research use only. Not medical advice.
This is a living archive of historical and continually changing material — published papers, regulatory documents, public commentary and community accounts — gathered for research and personal reference. It is not a clinical resource: nothing here is a diagnosis, a treatment recommendation, or dosing guidance, and a statement being recorded here does not make it true.
Records are summarized in our own words; summaries can be incomplete or out of date, and sources can be corrected or retracted after they were collected. Always read the original source, and talk to a qualified clinician before acting on anything you read here.
If you are struggling or thinking about suicide, please reach out now: call or text 988 in the US, call 116 123 (Samaritans) in the UK & Ireland, or contact your local emergency number.
John Taverna, MPH
Epidemiologist · Chief Analytics Officer · Public health researcher
John Taverna is an epidemiologist and healthcare analytics leader: Chief Analytics Officer at Urban Health Plan, a network of federally qualified health centers in New York City, and formerly a public health data systems lead at the NYC Department of Health and Mental Hygiene.
MPH in Epidemiology & Biostatistics and Health Policy & Management, CUNY Hunter College.
17+ years in healthcare and public health analytics in New York City, including the design of the city’s first real-time distributed population-health surveillance system (JAMIA, 2012).
This is a work in progress. Spotted an error, a retraction or a missing paper? Get in touch via jtaverna.org.
Disclosure: Curation choices and views are the curator’s own and do not represent any employer.
Every record is a card with its source, date (as the source states it — relative Reddit dates are never recomputed), verification status, and a note on why it is in the corpus. Badges flag anything that needs care:
Summaries, abstracts and key points are paraphrases, not quotations. The only verbatim text is clearly labelled: the third-party posts that Dr Powers was replying to, and recovered post bodies. Those posts often describe their authors’ own health, so their Reddit usernames are removed throughout the site and its downloads.
Every record belongs to exactly one collection. The Library opens on all of them; the main corpus or a curated collection is one click away. How each collection was gathered is set out in the methodology.
| Collection | Records | What it is |
|---|---|---|
| Core corpus core | 261 | Original corpus content (peer-reviewed lit, Powers commentary, transcripts, ICD codes, medications, datasets, glossary, timeline, mechanism matrix, open questions, gene library records, Powers gene findings). Includes PSSD-003, which is additionally flagged starred/curated_source='PSSD discord'. |
| PSSD Discord picks pssd-discord Curated | 28 | Curated from the PSSD Discord 'Papers & Resources Mentioned' list (Oct 2026); all carry starred: true and curated_source: 'PSSD discord'. |
| Powers Reddit history powers-reddit-history Curated | 89 | Curated from the user-provided u/drwillpowers Reddit history export (Oct 2026); all carry starred: true and curated_source: 'Powers Reddit history (John-provided export)'. |
| Literature sweep · Oct 2026 literature-sweep-2026-10 | 77 | Systematic literature sweep of 2026-10-07 (5 axes: PFS clinical/neurosteroid, PSSD, post-retinoid/post-drug syndromes, mechanistic pillars, regulatory/gray); not starred; carries sweep_date. |
| Epigenetics supplement · Oct 2026 epigenetics-supplement-2026-10 | 15 | Targeted 2026-10-07 follow-up sweep filling the persistence-mechanism gap (finasteride/SSRI/isotretinoin epigenetics, SRD5A2 methylation, DNA-damage/integrity, antidepressant-epigenetics background); not starred; carries sweep_date; verified via OpenAlex + Crossref. |
| SIDEfxHUB picks sidefxhub Curated | 11 | SIDEfxHUB cross-check intake (Oct 2026): 11 new verified candidates from the SIDEfxHUB Research & Insights list, all starred |
| Systems review · Oct 2026 systems-review-2026-10 | 48 | Systems literature review (Oct 2026): 48 verified papers across 8 bodily/mechanistic systems, each with system_classification + justification for causal-pathway and treatment-candidate branching. Not starred. |
| Researcher list · Oct 2026 researcher-list-2026-10 | 4 | Researcher-supplied paper list (Oct 2026): 4 papers missing from the corpus, verified and staged (RES-001…004). Not starred. |
| Curator additions curator-additions | 3 | Curator additions (Oct 2026 onward): sources the curator adds one at a time between sweeps, from user submissions, the news scout and the curator's own finds; each drafted and approved in corpus-build/additions/. Not starred. |
Raw material stays out of the public library: the full Reddit-history archive and its index, gene-library fetch audit trails, per-axis sweep working files and build scripts. Video transcript files are listed on their records but not yet bundled.
The complete release in a public edition: identical to the maintainers’ release except that private individuals’ Reddit usernames are replaced with “[username removed]”. Dr Powers’ own handle is kept. Row order matches the numbered catalog.