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Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
Not medical advice. A living research archive of historical and continually changing sources, for research and personal reference only. Summaries are paraphrases — verify against the originals. Full disclaimer
How cholesterol becomes progesterone, testosterone and the neurosteroids that act on the brain's GABA-A receptor, with 5α-reductase, the enzyme finasteride and dutasteride block, at the centre.
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How the body switches androgens and other steroids off and gets rid of them: conjugation by glucuronidation and sulfation, export from cells, and the exits through urine and bile, where gut bacteria can undo the work and send steroids back.
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How testosterone and DHT act: the receptor waiting in its chaperone complex, binding hormone, moving into the nucleus and switching genes on with its coregulators, and the gene and epigenetic settings that tune how strongly it responds.
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How serotonin and dopamine are made, released, taken back up and broken down; the receptors behind desire, arousal, orgasm and reward; and where SSRIs act. The pathway most discussed for post-SSRI sexual dysfunction (PSSD).
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How vitamin A becomes retinoic acid and switches genes on through the RAR and RXR receptors, where isotretinoin enters, and the enzymes that work on both retinoids and androgens. The pathway behind post-retinoid sexual dysfunction (PRSD).
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A zoomable, searchable map of the whole library, connected by idea and category, with these pathway maps as its detailed views.