Possible PFS Mechanism Identified — Help Us Gather Patient Data
not u/drwillpowers
not verified (video page crawled ~199 days before 2026-10-07)
Presents Dr Will Powers’ theory
Summary (paraphrased)
The video presents Powers' Reddit post on a newly identified candidate PFS mechanism and organizes community data collection around three tests: a morning hormone panel, a blood androstanediol glucuronide test, and the DUTCH urine steroid test, with strict collection rules (fasted, morning, no exercise or sexual activity for 12h, consistent TRT timing). It reflects how his Reddit theorizing translated into a concrete biomarker protocol adopted by the patient community.
Why it’s in the corpus
Documents the operational side of Powers' PFS research: which labs/biomarkers he considers informative (urinary androgen metabolites, glucuronidated androgens). Useful for the corpus's methods/biomarker section.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit postCurated Powers pick
As promised, this post contains the document I've made that summarizes the lab findings I personally suspect a...
u/drwillpowers · r/DrWillPowers
Post body unavailable. From the title (truncated in the export), Powers published a document summarizing the laboratory findings he personally suspects are associated with PFS — evidently a promised deliverable consolidating his biomarker observations (the…
PRH-11532026-04-27T22:35:13ZPFSPowers Reddit history - Powers · Reddit post
I think I have figured out at least one specific phenotype of PFS, and it is different from the "allopregnanolone" theory
u/drwillpowers · r/DrWillPowers
Powers' key genetics-first post: he proposed a specific PFS phenotype whose "base, core defect" is defective UGT2B17, disabling testosterone's main glucuronidation exit pathway. Carriers show shockingly low 3α-androstanediol glucuronide and near-zero urinary…
AKR1C1AKR1C2AKR1C3AKR1C4HSD17B2+3DWP-0032026PFSCore corpus - Powers · Reddit commentCurated Powers pick
Re: I collect more and more labsgenomedutch tests…
u/drwillpowers · r/DrWillPowers
Powers lists his diagnostic array for PFS: blood testosterone, blood DHT, blood DHEAS, blood 3α-androstanediol glucuronide, a urinary DUTCH complete panel, and whole-genome sequencing reviewed against the gene list from his posts. He claims he has yet to find…
PRH-13442026-04-05T17:54:43ZPFSPowers Reddit history