Post-finasteride syndrome - a true clinical entity?

This 2025 review critically appraises whether post-finasteride syndrome constitutes a genuine clinical entity. The authors survey its reported sexual, neuropsychiatric, and physical manifestations and the proposed mechanisms — neurobiological alterations and genetic predisposition — while engaging the controversy over its existence and medical recognition. They conclude that affected men can develop a substantial burden of physical and psychological symptoms, stressing patient education, pre-prescription risk assessment, and a multidisciplinary research and policy response.