SULT2A1 Gene Copy Number Variation is Associated with Urinary Excretion Rate of Steroid Sulfates
Merged into MECH-019
Deduplicated in corpus v1.10: this record described the same paper as MECH-019 (DOI 10.3389/fendo.2013.00088, SULT2A1 copy-number variation and urinary steroid sulfate excretion). MECH-019 is the canonical record; its PMID (23874324) was recovered from this duplicate. Kept as a tombstone per the no-silent-deletions policy — do not count as a separate paper. Open MECH-019 →
Related records
- Powers · Reddit post
I think I have figured out at least one specific phenotype of PFS, and it is different from the "allopregnanolone" theory
u/drwillpowers · r/DrWillPowers
Powers' key genetics-first post: he proposed a specific PFS phenotype whose "base, core defect" is defective UGT2B17, disabling testosterone's main glucuronidation exit pathway. Carriers show shockingly low 3α-androstanediol glucuronide and near-zero urinary…
AKR1C1AKR1C2AKR1C3AKR1C4HSD17B2+3DWP-0032026PFSCore corpus - Powers gene claim
SULT2A1 — weakening mutations
Confidence: direct
Weakening mutations in SULT2A1 impair the sulfation exit route for testosterone, amplifying the glucuronidation defect.
SULT2A1PGL-SULT2A1circa May 2026PFSCore corpus - Powers · Reddit postCurated Powers pick
Had another random PSSD/PFS thought about the glucuronidation theory. Do any of you with PFS have elevated sul...
u/drwillpowers · r/DrWillPowers
Post body unavailable. From the title (truncated in the export at "elevated sul…"), Powers shared a new thought extending his glucuronidation theory and asked PFS patients whether they have elevated sulf- markers — in context, most plausibly…
SULT2A1PRH-14052026-03-30T19:44:12ZPFSPSSDPowers Reddit history