Re: Had another random pssdpfs thought about the…
u/drwillpowers
r/DrWillPowers2026-04-03T05:14:02Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Brief reply in the glucuronidation-theory thread. Powers proposes a selection bias: men who seek out finasteride do so because DHT is their predominant — possibly their only — metabolism pathway. High baseline DHT may therefore indicate underlying dysfunction, which finasteride then destroys by annihilating the patient's last remaining androgen exit path.
Key points (paraphrased)
- Selection bias: finasteride seekers are enriched for DHT-predominant metabolism.
- High baseline DHT as a possible marker of underlying dysfunction.
- Finasteride framed as destroying the last remaining exit pathway.
Why it’s in the corpus
A compact, testable hypothesis about who is at risk (baseline DHT predominance as a susceptibility marker) — relevant to the corpus's risk-stratification and screening discussion.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to a community member:
Following up from an earlier comment – would these imbalances/anomalies be present in someone before they developed PFS? I assume yes, as they originate from inborn errors of metabolism.
If so, getting comprehensive hormone testing would probably be a good way to "guess" if there is something wrong with one's endocrine system and thus whether they should take the risk with finasteride.
(Parent context recovered from the r.genit.al mirror on 2026-10-07; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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