Healthcare of the Transgender Patient (Powers Method)
William J. Powers, D.O., Powers Family Medicine
reupload (original: 2019 Medical Education Week, Oakland University William Beaumont School of Medicine) · ~1h 45m (per chapter list ending 1:45:27 Q&A)original lecture 2019-05-13; this reupload circa 2024 (approximate)
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Powers' full 2019 lecture on transgender patient care and "the Powers Method" of hormonal transitioning. While not about PFS/PSSD directly, it is the foundational on-camera record of Powers' endocrine reasoning — including extended discussion of estrone vs. estradiol, progesterone use, and androgen blockade — which informs his later commentary on 5-alpha-reductase inhibition, neurosteroid depletion, and hormone-pathway manipulation in post-drug syndromes. Alternate uploads: https://www.youtube.com/watch?v=qGuvDlYDNzU.
Why it’s in the corpus
background pharmacology: estrone, progesterone, testosterone blockers, neurosteroid-relevant endocrinology underlying Powers' later PFS commentary
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Video
Healthcare of the Transgender Patient (Powers Method)
William J. Powers, D.O. · Chen Merami · 2:03:27 (7407s)
background pharmacology: 5ARI neurosteroid depletion, rectal progesterone protocol, androgen blockade
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Has anyone here taken finasteride or dutasteride and gotten post finasteride syndrome (PFS) from them? I have a theory as to why this seems to happen in transgender women more than cis men
u/drwillpowers · r/asktransgender
Powers proposed that PFS stems from deficient allopregnanolone, a neurosteroid produced downstream of 5-alpha-reductase via the AKR1C enzyme family. He hypothesized that only people carrying decreased-function variants in AKR1C genes develop the syndrome when…
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Rethinking Reductase: The Case for Progesterone and DHT Balance in Men
unidentified presenter (Wellness By Design Project; not confirmed as Powers) · The Wellness By Design Project · 11:32 (692s)
5α/5β reductase biochemistry; allopregnanolone depletion in PFS; progesterone modulation
YT-17MNS2Z6kV02026-02-16PFSCore corpus