Possible PFS Mechanism Identified — Help Us Gather Patient Data
SIDEfxHUB (presenting Dr. Powers' Reddit-post theory)
SIDEfxHUB · unavailable via text fetchcirca March 2026 (approximate, inferred from index timestamp)
Presents Dr Will Powers’ theory
Summary (paraphrased)
SIDEfxHUB video built around a Dr Powers Reddit post presenting his candidate PFS mechanism, centered on a mutation finding in a patient. The video issues a call for PFS patients to contribute standardized test data: a morning fasted hormone panel, an androstanediol glucuronide blood test, and a DUTCH test, with strict pre-test rules (morning draw, 12h fast, no heavy exercise or sexual activity 12h prior, consistent TRT timing). Results were to be sent to SIDEfxHUB for aggregation. This is the primary YouTube artifact linking Powers' Reddit theorizing to an organized patient-data effort.
Why it’s in the corpus
PFS mechanism theory (Powers' Reddit post), patient data collection, hormone testing protocol
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- VideoAbout Powers’ work
Possible PFS Mechanism Identified — Help Us Gather Patient Data
SIDEfxHUB presenter (Robb) summarizing Dr. Will Powers' Reddit-post theory · SIDEfxHUB - PFS & PSSD Patient Organisation · 6:42 (402s)
PFS mechanism theory; biomarker protocol; community data collection for summit
YT-7iyhq47npE82026-03-08PFSCore corpus - Video
Dr. Will Powers Interview [PFS / PAS / PSSD Summit 2026]
Dr. Will Powers · SIDEfxHUB - PFS & PSSD Patient Organisation · 21:27 (1287s)
PFS, PAS, PSSD mechanism theory; Powers' unifying model; vulnerability screening
ARARID1ACHD8HDAC10YT-iWFDBRTgT3g2026-04-29PFSPSSDPRSDCore corpus - Powers · Reddit post
I think I have figured out at least one specific phenotype of PFS, and it is different from the "allopregnanolone" theory
u/drwillpowers · r/DrWillPowers
Powers' key genetics-first post: he proposed a specific PFS phenotype whose "base, core defect" is defective UGT2B17, disabling testosterone's main glucuronidation exit pathway. Carriers show shockingly low 3α-androstanediol glucuronide and near-zero urinary…
AKR1C1AKR1C2AKR1C3AKR1C4HSD17B2+3DWP-0032026PFSCore corpus