Post-Finasteride Syndrome - Cause & Effect! (TRT-clinic short)
unidentified (TRT/HRT clinic channel)
Why it’s in the corpus
was: neurosteroid hypothesis of PFS (5α-reduced neurosteroids in CSF)
Related records
- Video
Rethinking Reductase: The Case for Progesterone and DHT Balance in Men
unidentified presenter (Wellness By Design Project; not confirmed as Powers) · The Wellness By Design Project · 11:32 (692s)
5α/5β reductase biochemistry; allopregnanolone depletion in PFS; progesterone modulation
YT-17MNS2Z6kV02026-02-16PFSCore corpus - Powers · Reddit post
Has anyone here taken finasteride or dutasteride and gotten post finasteride syndrome (PFS) from them? I have a theory as to why this seems to happen in transgender women more than cis men
u/drwillpowers · r/asktransgender
Powers proposed that PFS stems from deficient allopregnanolone, a neurosteroid produced downstream of 5-alpha-reductase via the AKR1C enzyme family. He hypothesized that only people carrying decreased-function variants in AKR1C genes develop the syndrome when…
DWP-0012020PFSCore corpus - Community accountAbout Powers’ workSelf-report · N=1
Why does PFS cause numbness only in the penis? 2 years off fin, sensation at 5–10%
u/various (r/DrWillPowers members) · r/DrWillPowers
A PFS patient with isolated genital numbness (normal systemic hormones, no cognitive symptoms) asked Powers about mechanisms for anatomically localized sensory loss — peripheral nerve vs. androgen-receptor vs. neurosteroid-driven sensory processing — and what…
DWP-0092026PFSPSSDCore corpus