Pathway map · 13 steps · 11 findings from 12 sources

Retinoid signalling

How vitamin A becomes retinoic acid and switches genes on through the RAR and RXR receptors, where isotretinoin enters, and the enzymes that work on both retinoids and androgens. The pathway behind post-retinoid sexual dysfunction (PRSD).

A research map, not medical advice

The map shows where the library’s evidence sits on a pathway; it doesn’t show that any step causes a post-drug syndrome, and it says nothing about treatment. Dr Powers’ layer is his unpublished theorizing and is off until you switch it on.

Reading the evidence

The textbook steps here come from Reactome and the gene library's UniProt annotation; the library has few studies of this pathway in people with PRSD.
Most of the clinical evidence on isotretinoin and sexual function concerns effects during treatment, and two reviews call it conflicting and of low quality; persistence after stopping is rarely measured.
Isotretinoin is 13-cis-retinoic acid: it acts partly by turning into all-trans retinoic acid and partly, in reporter cells, on the RARα receptor directly.
The textbook steps come from Reactome (CC BY 4.0) where it has the reaction, and otherwise from reviews in the library. Each step’s sources are listed when you select it.

All pathway maps

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Reading the evidence

The textbook steps here come from Reactome and the gene library's UniProt annotation; the library has few studies of this pathway in people with PRSD.

Most of the clinical evidence on isotretinoin and sexual function concerns effects during treatment, and two reviews call it conflicting and of low quality; persistence after stopping is rarely measured.

Isotretinoin is 13-cis-retinoic acid: it acts partly by turning into all-trans retinoic acid and partly, in reporter cells, on the RARα receptor directly.

The textbook steps come from Reactome (CC BY 4.0) where it has the reaction, and otherwise from reviews in the library. Each step’s sources are listed when you select it.