17β-Hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties
Angelika Friedel; Hans Geyer; Matthias Kamber; Ute Laudenbach-Leschowsky; Wilhelm Schänzer; Mario Thevis; Günter Vollmer; Oliver Zierau; Patrick Diel
Toxicology Letters2006
Summary (paraphrased)
The only controlled pharmacology study of dihydroboldenone (1-testosterone, DHB): in castrated rats, equimolar 1-testosterone matched testosterone propionate in stimulating levator ani, ventral prostate, and seminal vesicle growth, with an anabolic/androgenic profile comparable to the reference androgen, while also increasing liver weight. In a yeast androgen-receptor transactivation assay it proved a potent AR agonist without requiring metabolic activation. The authors flag it as a fully active, non-aromatizing anabolic steroid with hepatic effects. Almost nothing else in the peer-reviewed literature characterizes this compound.
Why it’s in the systems review
Community members inject DHB, and Powers theorizes it stacks as glucuronidated metabolites when UGT2BXX function is defective; this paper is the only rigorous pharmacology of the parent compound — potency, tissue effects, hepatic activity, AR agonism without metabolic activation. Without it, the corpus would discuss DHB entirely from forum anecdote. It also establishes DHB as a powerful non-aromatizing androgen, relevant to androgen-trapping hypotheses.
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