Multiple roles for UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution
Gauthier-Landry L, Bélanger A, Barbier O
Journal of Steroid Biochemistry and Molecular Biology2015 (epub 2014)
Summary (paraphrased)
Review of two glucuronidation enzymes, UGT2B15 and UGT2B17, that convert DHT metabolites (3α-diol and androsterone) into inactive, easily excreted glucuronide conjugates. It describes how these enzymes control local androgen availability and androgen-receptor signaling in prostate tissue, shape responses to anti-androgen drugs, and how AR and its splice variants regulate the enzymes' expression. It closes by asking whether the AR–UGT axis could serve as a prognostic marker or drug target.
Why it’s in the corpus
UGT2B17 is Dr Will Powers' theorized core defect in PFS (corpus DWP-003); this review details exactly how UGT2B17 clears androgenic steroids, grounding post-drug androgen-signaling and pharmacogenetic hypotheses.
Related records
- Peer-reviewed paper
UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response
Sarah Chouinard; Olivier Barbier; Alain Bélanger · Journal of Biological Chemistry
The UGT2B15 and UGT2B17 enzymes conjugate dihydrotestosterone and its metabolites androstane-3α,17β-diol and androsterone. Both enzymes are present in epithelial cells of the human prostate, where significant concentrations of the corresponding glucuronides…
UGT2B15UGT2B17MECH-0492007Systems review · Oct 2026 - Powers · Reddit post
I think I have figured out at least one specific phenotype of PFS, and it is different from the "allopregnanolone" theory
u/drwillpowers · r/DrWillPowers
Powers' key genetics-first post: he proposed a specific PFS phenotype whose "base, core defect" is defective UGT2B17, disabling testosterone's main glucuronidation exit pathway. Carriers show shockingly low 3α-androstanediol glucuronide and near-zero urinary…
AKR1C1AKR1C2AKR1C3AKR1C4HSD17B2+3DWP-0032026PFSCore corpus - Powers · Reddit commentCurated Powers pick
Re: Had another random pssdpfs thought about the…
u/drwillpowers · r/DrWillPowers
Reply to a community member's glucuronidation-theory thought about sulfation labs. Powers notes the discussed factor interacts with androgen production and ABCC-family transporters (he believes ABCB1 specifically, with the caveat that he read it long ago)…
ABCB1LRP2UGT2B15UGT2B17UGT2B7PRH-13982026-04-01T15:22:34ZPFSPSSDPowers Reddit history