Re: I collect more and more labsgenomedutch tests…
u/drwillpowers
r/DrWillPowers2026-04-07T23:08:11Z
Dr Will Powers’ own statements and theorizing
Summary (paraphrased)
Powers says he has few PSSD genomes so far; his working model mirrors PFS — inborn anomalies create a fragile system that cannot adapt to the drug — with a second group that adapts while on the drug but fails epigenetic reprogramming after stopping. His PSSD hunches, he says, center on intracellular metabolite trapping and cAMP-concentration-gradient signaling anomalies: a baseline glitch the system can adapt to, until the drug adds an extra load it cannot.
Key points (paraphrased)
- PSSD theory status at the time: early, pattern-hunting; few genomes available.
- Same two-group model as PFS: fragile baseline vs. failed post-drug epigenetic re-adaptation.
- Hunches: intracellular metabolite trapping and cAMP-gradient signaling anomalies.
- Baseline glitch + drug overload as the shared structure across post-drug syndromes.
Why it’s in the corpus
A status snapshot of the PSSD theory when it was still pattern-hunting. The cAMP-gradient angle introduced here recurs as his pointer for numbness/anhedonia.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], a PSSD and long-COVID sufferer who asked whether he has tested many PSSD or long-COVID patients and praised the genetic-effect framing, in Powers' labs/genomes/DUTCH theory thread.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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