HTR2C
5-hydroxytryptamine receptor 2C
Gene summary
A protein-coding gene on chromosome X (neurotransmission). Encodes a seven-transmembrane G-protein-coupled receptor. The protein responds to signaling through the neurotransmitter serotonin.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
5-hydroxytryptamine receptor 2C
- Function (excerpt)
G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.
- Subcellular location
Cell membrane.
- Tissue specificity
Detected in brain.
Source: UniProtKB/Swiss-Prot P28335, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).
Written for the whole neurotransmission family, not for HTR2C specifically.
Mentioned in 4 corpus records
- Powers · Reddit commentCurated Powers pick
Re: Why does calcium d glucarate cause anxiety…
u/drwillpowers · r/DrWillPowers
Answer to why calcium D-glucarate causes anxiety. Powers explains it downstream of his core model: buildup of two identified neurosteroids produces chronic GABA-A positive allosteric modulation — like constant endogenous Xanax — forcing downstream systems…
HTR1AHTR2CPRH-01342026-09-16T16:41:07ZPSSDPowers Reddit history - Powers · Reddit commentCurated Powers pick
Re: CDG Theory
u/drwillpowers · r/DrWillPowers
Powers gave a deliberately simple account of calcium D-glucarate: as a beta-glucuronidase inhibitor it causes glucuronidated compounds and catechols to be dumped into the gut and lost rather than reabsorbed, leaving COMT (catechol-O-methyltransferase) with…
COMTHTR2CPRH-05602026PFSPSSDPRSDPowers Reddit history - Powers · Reddit postCurated Powers pick
I'm starting to see trends in PSSD genomes, this is one. DBH
u/drwillpowers · r/DrWillPowers
Post body unavailable. From the title, Powers announced he was beginning to see recurring trends in the genomes of his PSSD patients, singling out DBH — dopamine beta-hydroxylase, the enzyme converting dopamine to norepinephrine — as one such trend. This is…
COMTDBHHTR2CUGT2B17PRH-07452026-06-11T23:41:29ZPFSPSSDPowers Reddit history - Powers · Reddit commentCurated Powers pick
PFS claimed to rest on an overwhelming evidence base; PSSD mechanism still open and possibly multiple
u/drwillpowers · r/DrWillPowers
Replying to a community member's 3α-HSD oxidation-inhibition proposal — fluoxetine inhibiting allopregnanolone oxidation via RoDH-4 as the direct drug→metabolite-accumulation link — Powers contrasts the two syndromes: PFS, he says, rests on an overwhelming…
HTR2CPRH-15162026-06-19T23:06:28ZPFSPSSDPowers Reddit history
Also in neurotransmission
All 54 genes- SLC6A4
solute carrier family 6 member 4
chr 17· Drug transporters· 10 records - HTR1A
5-hydroxytryptamine receptor 1A
chr 5· Neurotransmission· 6 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - DBH
dopamine beta-hydroxylase
chr 9· Neurotransmission· 3 records - BDNF
brain derived neurotrophic factor
chr 11· Neurotransmission· 2 records - DRD1
dopamine receptor D1
chr 5· Neurotransmission· 1 record - DRD2
dopamine receptor D2
chr 11· Neurotransmission· 1 record - HTR2A
5-hydroxytryptamine receptor 2A
chr 13· Neurotransmission· 1 record
Browse by family on the gene families page.