Re: Im a doctor who treats both pfs and pssd im…
u/drwillpowers
r/PSSD2026-07-10T23:35:35Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
In the r/PSSD thread where he introduced himself as a doctor treating both conditions, Powers gives his current ranking of SSRI effects on allopregnanolone: SSRIs whose names begin with F raise it; paroxetine raises it slightly; the rest are slightly to considerably negative. He presents this as his current understanding, explicitly open to counterexamples, and notes he states things in oddly direct ways.
Key points (paraphrased)
- F-named SSRIs raise allopregnanolone; paroxetine slightly positive; the rest slightly to considerably negative.
- Presented as current understanding, explicitly open to counterexamples.
- Context: choosing SSRIs for PFS patients needing allopregnanolone support without risking PSSD.
- Answers his own clinical question posed to the PSSD community; includes his caveat about stating things in oddly direct ways.
Why it’s in the corpus
A concrete, citable SSRI ranking for the neurosteroid framing of PSSD — directly relevant to treatment-choice discussions and to interpreting differential SSRI effects.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who clarified they had misread his statement as claiming fluvoxamine was neutral/negative on allopregnanolone; Powers confirmed the correction. The thread OP (Powers himself) had asked the PSSD community about SSRI options that raise allopregnanolone without worsening PSSD.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit commentCurated Powers pick
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