Post-SSRI Sexual Dysfunction: Clinical Characterization and Preliminary Assessment of Contributory Factors and Dose-Response Relationship
Ben-Sheetrit, Joseph; Aizenberg, Dov; Csoka, Antonei B.; Weizman, Abraham; Hermesh, Haggai
Journal of Clinical Psychopharmacology · 35(3):273-2782015
Abstract (paraphrased)
Survey of 532 respondents identified 183 possible PSSD cases (23 high-probability); female sex, genital anesthesia and depression predicted current severity, but dose did not; genital anesthesia was independent of depression/anxiety.
Plain-language summary (paraphrased)
The largest systematic survey of PSSD at the time found that genital numbness is the hallmark symptom — and crucially, it occurred independently of depression, proving it isn't "just the depression coming back." Higher doses didn't predict worse outcomes, again pointing to individual vulnerability.
Why it’s in the corpus
Best clinical characterization of PSSD; genital anesthesia as the differentiator from depressive relapse; no dose-response supports susceptibility model.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Peer-reviewed paper
Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors
Peleg, L. C.; Rabinovitch, D.; Lavie, Y.; et al. · Sexual Medicine Reviews · 10:91-98
Reviews neurobiological hypotheses for PSSD and lists presumed risk factors: prior exposure to certain drugs, genetic predisposition, psychological/chemical stress reactions, and pre-existing conditions affecting neuroplasticity; proposes a future research…
PSSD-0022022PFSPSSDCore corpus - Peer-reviewed paper
Post-SSRI Sexual Dysfunction: A Literature Review
Bala, Areeg; Nguyen, Hoang Minh Tue; Hellstrom, Wayne J. G. · Sexual Medicine Reviews · 6(1):29-34
Comprehensive review of PSSD covering symptoms (genital anesthesia, pleasureless orgasm, low libido, ED), proposed mechanisms (epigenetic gene expression, 5-HT1A downregulation, dopamine-serotonin interactions, hormonal changes, serotonin neurotoxicity) and…
HTR1APSSD-0012018PFSPSSDCore corpus - Peer-reviewed paper
Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors
Csoka, Antonei B.; Bahrick, Audrey; Mehtonen, Olavi-Pekka · The Journal of Sexual Medicine · 5(1):227-233
Case reports of persistent sexual dysfunction (including genital anesthesia and ejaculatory anhedonia) lasting years after SSRI/SNRI discontinuation in previously healthy individuals; proposes medication-induced changes in gene expression as the mechanism.
PSSD-0042008PSSDCore corpus
