Advancing human gut microbiota research by considering gut transit time
Nicola Procházková; Gwen Falony; Lars Ove Dragsted; Tine Rask Licht; Jeroen Raes; Henrik M. Roager
Gut, 72(1):180-1912023
Summary (paraphrased)
Review arguing that gut transit time is a top covariate driving interindividual variation in gut microbiota composition and activity, yet is rarely accounted for in microbiome research. Faster transit favors carbohydrate fermentation and beneficial short-chain fatty acids; slower transit favors protein fermentation and less favorable by-products. The authors describe bidirectional links between transit time and microbiota and urge incorporating transit-time measures into microbiome study design to avoid confounded disease signatures.
Why it’s in the corpus
Mechanistic background for gut-brain axis discussion in PFS/PSSD; complements corpus PFS gut-microbiota papers (DISC-008/009/010). No direct PFS/PSSD link — background mechanism only.
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