Paroxetine effects in adult male rat colon: Focus on steroidogenesis and microbiota
Diviccaro, Silvia; Giatti, Silvia; Cioffi, Lucia; Falvo, E.; Piazza, R.; Caruso, Donatella; Melcangi, Roberto Cosimo
Psychoneuroendocrinology · 1432022
Abstract (paraphrased)
Paroxetine altered steroid synthesis and microbiota composition in rat colon, linking SSRI exposure to gut-steroid disruption relevant to the gut-brain axis.
Plain-language summary (paraphrased)
This study found that paroxetine changes both steroid production and gut bacteria in the colon — connecting the SSRI story to the gut-brain axis that the Milan group also implicates in PFS. It suggests the gut is another site where these drugs leave lasting effects.
Why it’s in the corpus
Gut-microbiota/steroid axis in PSSD; parallels the gut-brain mechanism proposed for PFS in the bridge review (PFS-003).
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Peer-reviewed paper
Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis
Diviccaro, Silvia; Giatti, Silvia; Cioffi, Lucia; Falvo, E.; Caruso, Donatella; Melcangi, Roberto Cosimo · Psychoneuroendocrinology · 132
In adult male rats, paroxetine treatment and its withdrawal altered neurosteroid synthesis pathways, showing SSRIs directly perturb neurosteroidogenesis beyond their serotonergic action.
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Post-Finasteride Syndrome And Post-SSRI Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Giatti, Silvia; Diviccaro, Silvia; Cioffi, Lucia; Melcangi, Roberto Cosimo · Frontiers in Neuroendocrinology · 72
Argues PFS and PSSD share overlapping clinical features (sexual dysfunction, psychological complaints, sleep disorders) and likely common mechanisms involving neuroactive steroids, serotonin/dopamine/catecholamine signaling and gut microbiota, possibly…
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Identification of a novel off-target of paroxetine: Possible role in sexual dysfunction induced by this SSRI antidepressant drug
Giatti, Silvia; Di Domizio, A.; Diviccaro, Silvia; Cioffi, Lucia; Marmorini, I.; Falvo, E.; Caruso, Donatella; Contini, A.; Melcangi… · Journal of Molecular Structure · 1268
Using in silico screening plus in vitro/in vivo assays, identified a novel protein off-target of paroxetine that may contribute to SSRI-induced sexual dysfunction, expanding the pharmacology beyond serotonin reuptake inhibition.
PSSD-0102022PSSDCore corpus