Pathway candidateNCBI-verifiedprotein-coding

ACE

angiotensin I converting enzyme

NCBI Gene: 1636 Ensembl GeneCards UniProt: P12821

Pathway candidate — not linked to PFS or PSSD by any record here

ACE is in the library because it belongs to the general physiology family. No study, report or commentary in the corpus names it, so a variant in ACE is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (general physiology). Encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Angiotensin-converting enzyme
Function (excerpt): Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins.
Subcellular location: Cell membrane; Cytoplasm; Secreted.
Tissue specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.
Associated conditions: Ischemic stroke (ISCHSTR); Renal tubular dysgenesis (RTD); Microvascular complications of diabetes 3 (MVCD3); Intracerebral hemorrhage (ICH).

Source: UniProtKB/Swiss-Prot P12821, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Established roles outside the core post-drug-syndrome pathways; no direct PFS/PSSD link established — included for completeness.

Written for the whole general physiology family, not for ACE specifically.

Mentioned in 0 corpus records

No corpus record names ACE directly yet. It is in the library because it sits in a pathway the corpus tracks (General physiology).

Also in general physiology

All 3 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Angiotensin-converting enzyme
Function (excerpt): Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins.
Subcellular location: Cell membrane; Cytoplasm; Secreted.
Tissue specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.
Associated conditions: Ischemic stroke (ISCHSTR); Renal tubular dysgenesis (RTD); Microvascular complications of diabetes 3 (MVCD3); Intracerebral hemorrhage (ICH).