AKR1B10
aldo-keto reductase family 1 member B10
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 7 (drug metabolism (phase i)). Encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Aldo-keto reductase family 1 member B10
- Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose.
- Pathway
Cofactor metabolism; retinol metabolism.
- Subcellular location
Lysosome; Secreted.
- Tissue specificity
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Source: UniProtKB/Swiss-Prot O60218, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects.
Written for the whole drug metabolism family, not for AKR1B10 specifically.
Mentioned in 0 corpus records
No corpus record names AKR1B10 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism).
Also in drug metabolism (phase i)
All 23 genes- CYP2D6
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
chr 22· Drug metabolism· 6 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr 7· Drug metabolism· 2 records - CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr 10· Drug metabolism· 1 record - CYP3A5
cytochrome P450 family 3 subfamily A member 5
chr 7· Drug metabolism· 1 record - MAOA
monoamine oxidase A
chr X· Drug metabolism· 1 record - AKR1B1
aldo-keto reductase family 1 member B
chr 7· Drug metabolism· Pathway candidate - ALDH1A1
aldehyde dehydrogenase 1 family member A1
chr 9· Drug metabolism· Pathway candidate
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