Pathway candidateNCBI-verifiedprotein-coding

ALDH1A1

aldehyde dehydrogenase 1 family member A1

Chromosome 9Drug metabolism retinoid signaling

NCBI Gene: 216 Ensembl GeneCards UniProt: P00352

Pathway candidate — not linked to PFS or PSSD by any record here

ALDH1A1 is in the library because it belongs to the drug metabolism / retinoid signaling family. No study, report or commentary in the corpus names it, so a variant in ALDH1A1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (drug metabolism (phase i)). The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Aldehyde dehydrogenase 1A1
Function (excerpt): Cytosolic dehydrogenase that catalyzes the NAD(+)-dependent irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.
Pathway: Cofactor metabolism; retinol metabolism (By similarity).
Subcellular location: Cytoplasm, cytosol; Cell projection, axon.
Tissue specificity: Expressed by erythrocytes (at protein level).

Source: UniProtKB/Swiss-Prot P00352, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects.

Written for the whole drug metabolism / retinoid signaling family, not for ALDH1A1 specifically.

Mentioned in 0 corpus records

No corpus record names ALDH1A1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism, retinoid signaling).

Also in drug metabolism (phase i)

All 23 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Aldehyde dehydrogenase 1A1
Function (excerpt): Cytosolic dehydrogenase that catalyzes the NAD(+)-dependent irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid. Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic. Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification.
Pathway: Cofactor metabolism; retinol metabolism (By similarity).
Subcellular location: Cytoplasm, cytosol; Cell projection, axon.
Tissue specificity: Expressed by erythrocytes (at protein level).