CHD4
chromodomain helicase DNA binding protein 4
Gene summary
A protein-coding gene on chromosome 12 (epigenetic regulation). The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
ATP-dependent chromatin remodeler CHD4
- Function
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis (By similarity).
- Subcellular location
Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
- Tissue specificity
Widely expressed.
- Associated conditions
Sifrim-Hitz-Weiss syndrome (SIHIWES).
Source: UniProtKB/Swiss-Prot Q14839, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.
Written for the whole epigenetic regulation family, not for CHD4 specifically.
Mentioned in 1 corpus record
- Powers · Reddit commentCurated Powers pick
Re: Questions regarding current PFS theory
u/drwillpowers · r/DrWillPowers
Answering questions about variable onset and post-cessation crashes, Powers gives three linked explanations. First, milder or slower onsets reflect fewer defects — it takes longer to reach threshold. Second, people who crash on quitting had upregulated…
ARID1ACHD4CHD5CHD6CHD7+3PRH-15012026-04-18T08:57:02ZPFSPowers Reddit history
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chromodomain helicase DNA binding protein 6
chr 20· Epigenetic regulation· 1 record - CHD7
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