CHD6
chromodomain helicase DNA binding protein 6
Gene summary
A protein-coding gene on chromosome 20 (epigenetic regulation). Encodes a member of the SNF2/RAD54 helicase protein family. The protein contains two chromodomains, a helicase domain, and an ATPase domain.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
ATP-dependent chromatin remodeler CHD6
- Function
ATP-dependent chromatin-remodeling factor. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.
- Subcellular location
Nucleus, nucleoplasm.
- Tissue specificity
Widely expressed.
Source: UniProtKB/Swiss-Prot Q8TD26, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Epigenetic persistence is the leading hypothesis for why post-drug syndromes endure after the drug is gone; chromatin regulators are therefore priority candidates in any persistence mechanism.
Written for the whole epigenetic regulation family, not for CHD6 specifically.
Mentioned in 1 corpus record
- Powers · Reddit commentCurated Powers pick
Re: Questions regarding current PFS theory
u/drwillpowers · r/DrWillPowers
Answering questions about variable onset and post-cessation crashes, Powers gives three linked explanations. First, milder or slower onsets reflect fewer defects — it takes longer to reach threshold. Second, people who crash on quitting had upregulated…
ARID1ACHD4CHD5CHD6CHD7+3PRH-15012026-04-18T08:57:02ZPFSPowers Reddit history
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