COMTD1
catechol-O-methyltransferase domain containing 1
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 10 (drug metabolism (phase i), neurotransmission). Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Catechol O-methyltransferase domain-containing protein 1
- Function
Putative O-methyltransferase.
- Subcellular location
Membrane.
Source: UniProtKB/Swiss-Prot Q86VU5, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects. Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).
Written for the whole drug metabolism / neurotransmission family, not for COMTD1 specifically.
Mentioned in 0 corpus records
No corpus record names COMTD1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism, Neurotransmission).
Also in drug metabolism (phase i)
All 23 genes- CYP2D6
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
chr 22· Drug metabolism· 6 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr 7· Drug metabolism· 2 records - CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr 10· Drug metabolism· 1 record - CYP3A5
cytochrome P450 family 3 subfamily A member 5
chr 7· Drug metabolism· 1 record - MAOA
monoamine oxidase A
chr X· Drug metabolism· 1 record - AKR1B1
aldo-keto reductase family 1 member B
chr 7· Drug metabolism· Pathway candidate - AKR1B10
aldo-keto reductase family 1 member B10
chr 7· Drug metabolism· Pathway candidate
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