CYP3A43
cytochrome P450 family 3 subfamily A member 43
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 7 (drug metabolism (phase i)). Encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Cytochrome P450 3A43
- Function
Exhibits low testosterone 6-beta-hydroxylase activity in vitro. The physiological substrate of this enzyme is unknown.
- Subcellular location
Endoplasmic reticulum membrane; Microsome membrane.
- Tissue specificity
Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.
Source: UniProtKB/Swiss-Prot Q9HB55, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects.
Written for the whole drug metabolism family, not for CYP3A43 specifically.
Mentioned in 0 corpus records
No corpus record names CYP3A43 directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism).
Also in drug metabolism (phase i)
All 23 genes- CYP2D6
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
chr 22· Drug metabolism· 6 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr 7· Drug metabolism· 2 records - CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr 10· Drug metabolism· 1 record - CYP3A5
cytochrome P450 family 3 subfamily A member 5
chr 7· Drug metabolism· 1 record - MAOA
monoamine oxidase A
chr X· Drug metabolism· 1 record - AKR1B1
aldo-keto reductase family 1 member B
chr 7· Drug metabolism· Pathway candidate - AKR1B10
aldo-keto reductase family 1 member B10
chr 7· Drug metabolism· Pathway candidate
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