Pathway candidateNCBI-verifiedprotein-coding

H6PD

hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

NCBI Gene: 9563 Ensembl GeneCards UniProt: O95479

Pathway candidate — not linked to PFS or PSSD by any record here

H6PD is in the library because it belongs to the steroid synthesis family. No study, report or commentary in the corpus names it, so a variant in H6PD is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 1 (steroid hormone synthesis). There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: GDH/6PGL endoplasmic bifunctional protein
Function (excerpt): Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum.
Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 (By similarity). Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) (By similarity).
Subcellular location: Endoplasmic reticulum lumen.
Tissue specificity: Present in most tissues examined, strongest in liver.
Associated conditions: Cortisone reductase deficiency 1 (CORTRD1).

Source: UniProtKB/Swiss-Prot O95479, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.

Written for the whole steroid synthesis family, not for H6PD specifically.

Mentioned in 0 corpus records

No corpus record names H6PD directly yet. It is in the library because it sits in a pathway the corpus tracks (Steroid synthesis).

Also in steroid hormone synthesis

All 38 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: GDH/6PGL endoplasmic bifunctional protein
Function (excerpt): Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity). May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity). The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum.
Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3 (By similarity). Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage) (By similarity).
Subcellular location: Endoplasmic reticulum lumen.
Tissue specificity: Present in most tissues examined, strongest in liver.
Associated conditions: Cortisone reductase deficiency 1 (CORTRD1).