Pathway candidateNCBI-verifiedprotein-coding

HSD17B10

hydroxysteroid 17-beta dehydrogenase 10

NCBI Gene: 3028 Ensembl GeneCards UniProt: Q99714

Pathway candidate — not linked to PFS or PSSD by any record here

HSD17B10 is in the library because it belongs to the steroid synthesis family. No study, report or commentary in the corpus names it, so a variant in HSD17B10 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome X (steroid hormone synthesis). Encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 3-hydroxyacyl-CoA dehydrogenase type-2
Function (excerpt): Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism. Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA. Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway. Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids.
Pathway: Amino-acid degradation; L-isoleucine degradation. Lipid metabolism; fatty acid beta-oxidation. Steroid metabolism. Lipid metabolism; bile acid biosynthesis.
Subcellular location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid.
Tissue specificity: Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.
Associated conditions: HSD10 mitochondrial disease (HSD10MD).

Source: UniProtKB/Swiss-Prot Q99714, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.

Written for the whole steroid synthesis family, not for HSD17B10 specifically.

Mentioned in 0 corpus records

No corpus record names HSD17B10 directly yet. It is in the library because it sits in a pathway the corpus tracks (Steroid synthesis).

Also in steroid hormone synthesis

All 38 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 3-hydroxyacyl-CoA dehydrogenase type-2
Function (excerpt): Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism. Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA. Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway. Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids.
Pathway: Amino-acid degradation; L-isoleucine degradation. Lipid metabolism; fatty acid beta-oxidation. Steroid metabolism. Lipid metabolism; bile acid biosynthesis.
Subcellular location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid.
Tissue specificity: Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.
Associated conditions: HSD10 mitochondrial disease (HSD10MD).