Pathway candidateNCBI-verifiedprotein-coding

HSD17B12

hydroxysteroid 17-beta dehydrogenase 12

NCBI Gene: 51144 Ensembl GeneCards UniProt: Q53GQ0

Pathway candidate — not linked to PFS or PSSD by any record here

HSD17B12 is in the library because it belongs to the steroid synthesis family. No study, report or commentary in the corpus names it, so a variant in HSD17B12 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 11 (steroid hormone synthesis). Encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Very-long-chain 3-oxoacyl-CoA reductase
Function: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Pathway: Lipid metabolism; fatty acid biosynthesis. Steroid biosynthesis; estrogen biosynthesis.
Subcellular location: Endoplasmic reticulum membrane.
Tissue specificity: Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.

Source: UniProtKB/Swiss-Prot Q53GQ0, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.

Written for the whole steroid synthesis family, not for HSD17B12 specifically.

Mentioned in 0 corpus records

No corpus record names HSD17B12 directly yet. It is in the library because it sits in a pathway the corpus tracks (Steroid synthesis).

Also in steroid hormone synthesis

All 38 genes

Browse by family on the gene families page.

Protein reference (UniProt)

Protein: Very-long-chain 3-oxoacyl-CoA reductase
Function: Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Pathway: Lipid metabolism; fatty acid biosynthesis. Steroid biosynthesis; estrogen biosynthesis.
Subcellular location: Endoplasmic reticulum membrane.
Tissue specificity: Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.