Pathway candidateNCBI-verifiedprotein-coding

HSD17B3

hydroxysteroid 17-beta dehydrogenase 3

NCBI Gene: 3293 Ensembl GeneCards UniProt: P37058

Pathway candidate — not linked to PFS or PSSD by any record here

HSD17B3 is in the library because it belongs to the steroid synthesis family. No study, report or commentary in the corpus names it, so a variant in HSD17B3 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 9 (steroid hormone synthesis). This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 17-beta-hydroxysteroid dehydrogenase type 3
Function: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
Pathway: Hormone biosynthesis; testosterone biosynthesis. Steroid metabolism.
Subcellular location: Endoplasmic reticulum.
Tissue specificity: Testis.
Associated conditions: Male pseudohermaphrodism with gynecomastia (MPH).

Source: UniProtKB/Swiss-Prot P37058, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Steroid-synthesis enzymes sit directly on the pathways perturbed by 5-alpha-reductase inhibitors and SSRIs; inherited variation here is a candidate susceptibility factor for persistent post-drug phenotypes.

Written for the whole steroid synthesis family, not for HSD17B3 specifically.

Mentioned in 0 corpus records

No corpus record names HSD17B3 directly yet. It is in the library because it sits in a pathway the corpus tracks (Steroid synthesis).

Also in steroid hormone synthesis

All 38 genes

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Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: 17-beta-hydroxysteroid dehydrogenase type 3
Function: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
Pathway: Hormone biosynthesis; testosterone biosynthesis. Steroid metabolism.
Subcellular location: Endoplasmic reticulum.
Tissue specificity: Testis.
Associated conditions: Male pseudohermaphrodism with gynecomastia (MPH).