Pathway candidateNCBI-verifiedprotein-coding

KPNB1

karyopherin subunit beta 1

NCBI Gene: 3837 Ensembl GeneCards UniProt: Q14974

Pathway candidate — not linked to PFS or PSSD by any record here

KPNB1 is in the library because it belongs to the nuclear transport family. No study, report or commentary in the corpus names it, so a variant in KPNB1 is not, by itself, evidence of anything related to post-drug syndromes.

Gene summary

A protein-coding gene on chromosome 17 (nuclear transport). Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins.

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Importin subunit beta-1
Function (excerpt): Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Cytoplasm; Nucleus envelope.

Source: UniProtKB/Swiss-Prot Q14974, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Why its pathway is in the library

Nucleoplasmic transport; general cellular function with no direct post-drug-syndrome link established.

Written for the whole nuclear transport family, not for KPNB1 specifically.

Mentioned in 0 corpus records

No corpus record names KPNB1 directly yet. It is in the library because it sits in a pathway the corpus tracks (Nuclear transport).

Also in nuclear transport

All 2 genes

XPO5
exportin 5
chr 6· RNA processing· Pathway candidate

Browse by family on the gene families page.

Gene summary

Source: NCBI Gene, accessed 2026-10-07.

Protein reference (UniProt)

Protein: Importin subunit beta-1
Function (excerpt): Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Subcellular location: Cytoplasm; Nucleus envelope.