XPO5
exportin 5
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome 6 (rna processing and mirna biogenesis, nuclear transport). Encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Exportin-5
- Function (excerpt)
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- Subcellular location
Nucleus; Cytoplasm.
- Tissue specificity
Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.
Source: UniProtKB/Swiss-Prot Q9HAV4, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
miRNA biogenesis and RNA handling; epigenetic-adjacent regulation with no direct post-drug-syndrome link established. Nucleoplasmic transport; general cellular function with no direct post-drug-syndrome link established.
Written for the whole rna processing / nuclear transport family, not for XPO5 specifically.
Mentioned in 0 corpus records
No corpus record names XPO5 directly yet. It is in the library because it sits in a pathway the corpus tracks (RNA processing, Nuclear transport).
Also in rna processing and mirna biogenesis
All 11 genes- DGCR8
DGCR8 microprocessor complex subunit
chr 22· RNA processing· Pathway candidate - DICER1
dicer 1, ribonuclease III
chr 14· RNA processing· Pathway candidate - DROSHA
drosha ribonuclease III
chr 5· RNA processing· Pathway candidate - FUS
FUS RNA binding protein
chr 16· RNA processing· Pathway candidate - HNRNPA1
heterogeneous nuclear ribonucleoprotein A1
chr 12· RNA processing· Pathway candidate - HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr 9· RNA processing· Pathway candidate - HNRNPU
heterogeneous nuclear ribonucleoprotein U
chr 1· RNA processing· Pathway candidate - LIN28A
lin-28 RNA binding posttranscriptional regulator A
chr 1· RNA processing· Pathway candidate
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