MAOB
monoamine oxidase B
Pathway candidate — not linked to PFS or PSSD by any record here
Gene summary
A protein-coding gene on chromosome X (drug metabolism (phase i), neurotransmission). The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
Amine oxidase [flavin-containing] B
- Function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
- Subcellular location
Mitochondrion outer membrane.
Source: UniProtKB/Swiss-Prot P27338, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Phase I enzymes determine exposure to finasteride, SSRIs, and other implicated drugs; variation here shapes the likelihood and persistence of adverse effects. Monoamine, GABA, glutamate, and cholinergic systems are the direct pharmacologic targets of SSRIs/SNRIs (PSSD) and the downstream effectors of neurosteroid signaling (PFS).
Written for the whole drug metabolism / neurotransmission family, not for MAOB specifically.
Mentioned in 0 corpus records
No corpus record names MAOB directly yet. It is in the library because it sits in a pathway the corpus tracks (Drug metabolism, Neurotransmission).
Also in drug metabolism (phase i)
All 23 genes- CYP2D6
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)
chr 22· Drug metabolism· 6 records - COMT
catechol-O-methyltransferase
chr 22· Drug metabolism· 4 records - CYP3A4
cytochrome P450 family 3 subfamily A member 4
chr 7· Drug metabolism· 2 records - CYP2C19
cytochrome P450 family 2 subfamily C member 19
chr 10· Drug metabolism· 1 record - CYP3A5
cytochrome P450 family 3 subfamily A member 5
chr 7· Drug metabolism· 1 record - MAOA
monoamine oxidase A
chr X· Drug metabolism· 1 record - AKR1B1
aldo-keto reductase family 1 member B
chr 7· Drug metabolism· Pathway candidate - AKR1B10
aldo-keto reductase family 1 member B10
chr 7· Drug metabolism· Pathway candidate
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