CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids
Muhammad Farooq, Edward J Kelly, Jashvant D Unadkat
Drug Metabolism and Disposition2016
Retracted — never cite this as evidence
Summary (paraphrased)
The authors challenged the dogma that CYP2D6 is non-inducible, showing that in sandwich-cultured human hepatocytes CYP2D6 mRNA, protein, and activity were robustly (>10-fold) induced by endogenous (cortisol, corticosterone) and exogenous (dexamethasone, prednisolone) corticosteroids — but that this induction was masked when culture medium contained routine supplemental dexamethasone. They linked the cortisol data to the observed ~2-3-fold CYP2D6 induction in late pregnancy. CRITICAL: this paper has been RETRACTED (retraction notice: Drug Metab Dispos. 2018 Sep;46(9):1360), shown on the PMC page. NOTE: the Discord list labeled this 'Urinary steroid profile (2013)' — that label is wrong; PMC4851303 is this 2016 CYP2D6 induction paper.
Why it’s in the corpus
Relevant to SSRI/SNRI metabolism (CYP2D6 clears many antidepressants) and to steroid-hormone interplay with drug-metabolizing enzymes — but it is RETRACTED, so its findings must not be treated as reliable evidence in the corpus.
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