Post-SSRI Sexual Dysfunction (PSSD): Biological Plausibility, Symptoms, Diagnosis, and Presumed Risk Factors
Peleg, L. C.; Rabinovitch, D.; Lavie, Y.; et al.
Sexual Medicine Reviews · 10:91-982022
Abstract (paraphrased)
Reviews neurobiological hypotheses for PSSD and lists presumed risk factors: prior exposure to certain drugs, genetic predisposition, psychological/chemical stress reactions, and pre-existing conditions affecting neuroplasticity; proposes a future research agenda and treatment algorithm.
Plain-language summary (paraphrased)
This review argues PSSD is biologically plausible and identifies who may be most vulnerable — including people with a genetic predisposition or prior exposure to other risky drugs. It proposes specific brain mechanisms for each symptom and sketches what future research and treatment should target.
Why it’s in the corpus
Directly addresses genetic predisposition and cross-drug vulnerability (relevant to finasteride→SSRI risk); the risk-factor framing the corpus needs.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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