Notes from the Editor Emeritus: Coincidental Epigenetics or Post-Finasteride Syndrome (PFS)?
Dow B. Stough
International Society of Hair Restoration Surgery (journal)2016
Summary (paraphrased)
2016 editorial from the hair-restoration surgery community raising the epigenetics question for post-finasteride syndrome — an early datapoint showing the drug-induced-epigenetics framing of PFS was in the air two years before Traish's 2018 review (PFS-002).
Why it’s in the corpus
Historical framing datapoint: the epigenetics hypothesis for PFS predates the peer-reviewed reviews. Useful for the corpus's intellectual- history layer, not as mechanistic evidence.
Related records
- Peer-reviewed paperPSSD Discord pickSIDEfxHUB pick
Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study
Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi… · Endocrine Connections
In this pilot case-control study, 16 PFS patients were compared with 36 controls who had never used finasteride: 18 surgical patients giving cerebrospinal fluid (2 of whom also gave blood) and 18 blood-only donors; controls' mean age was 40.8 years vs 34.5 in…
SRD5A1SRD5A2DISC-0252019PFSPSSDPSSD Discord picks - Conference abstract
Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A potential contributor to Post-Finasteride Syndrome
Churchill Jonadab Ihentuge, Antonei Benjamin Csoka · Physiology (Physiology Summit meeting abstract)
Conference abstract explicitly linking finasteride's epigenetic effects on dopaminergic signaling pathways to post-finasteride syndrome — the only abstract in this series that names PFS directly, tying the epigenetic mechanism to the clinical syndrome.
EPI-0092024PFSEpigenetics supplement · Oct 2026 - Peer-reviewed paperVenue unverified
Trazodone by epigenetic mechanism can reverse the post finasteride syndrome
Eric Almeida Xavier · Magna Scientia Advanced Research and Reviews
Single-author paper claiming trazodone can reverse post finasteride syndrome through an epigenetic mechanism. Included for completeness of the epigenetics-of-PFS record, not as vetted evidence.
EPI-0142023PFSEpigenetics supplement · Oct 2026