Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition
Churchill Jonadab Ihentuge, Antonei Benjamin Csoka
Journal of Pharmacology and Experimental Therapeutics2023
Summary (paraphrased)
Reports that finasteride induces epigenetic alteration of TMPRSS2 gene expression. The paper's framing concerns SARS-CoV-2 (TMPRSS2 is an androgen-regulated host protease), but the mechanistic finding is the point for this corpus: a 5-alpha-reductase inhibitor producing a measurable epigenetic change at an androgen-responsive locus — a direct precedent for lasting drug-induced epigenetic remodeling at androgen-signaling genes.
Why it’s in the corpus
Direct precedent that finasteride alters the epigenetic state of an androgen-regulated gene — the same class of locus (cf. SRD5A2 methylation, DISC-025) implicated in PFS persistence.
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