The post-finasteride syndrome: clinical manifestation of drug-induced epigenetics due to endocrine disruption
Traish, Abdulmaged M.
Current Sexual Health Reports · 10(3):88-1032018
Abstract (paraphrased)
Proposes that 5-alpha-reductase inhibitors act as endocrine disruptors, producing drug-induced epigenetic changes in gene expression that explain why symptoms persist after discontinuation.
Plain-language summary (paraphrased)
This is the paper that introduced the "drug-induced epigenetics" model of PFS. It argues finasteride doesn't just temporarily block an enzyme — it reprograms how genes are switched on and off, which is why the damage outlasts the drug itself.
Why it’s in the corpus
Origin of the epigenetic/endocrine-disruptor model; theoretical anchor for all PFS genetics work in the corpus.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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