Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia
Cauci, Sabina; Chiriacò, Giovanni; Cecchin, Erika; Toffoli, Giuseppe; Xodo, Serena; Stinco, Giuseppe; Trombetta, Carlo
Sexual Medicine · 5(1):e61-e712017
Abstract (paraphrased)
In 66 PFS patients, short/long (CAG)n and (GGN)n repeat lengths in the androgen receptor gene were associated with different symptom frequencies (libido loss, genital sensitivity changes, muscle tone, skin dryness, etc.), with a U-shaped pattern for some symptoms.
Plain-language summary (paraphrased)
This study looked at whether genes explain why only some finasteride users get lasting symptoms. It found that variations in the length of the androgen receptor gene were linked to which symptoms men developed — suggesting a genetic predisposition that could one day let doctors predict who's at risk before prescribing.
Why it’s in the corpus
The core genetic-susceptibility paper for PFS; directly supports the pharmacogenetic/precision-medicine angle of the corpus.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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