Influence of Androgen Receptor CAG Polymorphism on Sexual Function Recovery after Testosterone Therapy in Late-Onset Hypogonadism
Giacomo Tirabassi; Giovanni Corona; Andrea Biagioli; Eddi Buldreghini; Nicola delli Muti; Mario Maggi; Giancarlo Balercia
The Journal of Sexual Medicine2015
Summary (paraphrased)
Seventy-three men with late-onset hypogonadism were evaluated with the IIEF questionnaire and hormone panels before testosterone replacement therapy and again before their sixth testosterone injection. All sexual function domains improved with therapy, but the number of CAG repeats in the androgen receptor gene was negatively correlated with the degree of improvement in nearly every domain. In multivariable models, longer CAG tracts independently predicted smaller gains in erectile function and overall sexual function. The study is the first in a large cohort to show that this common AR polymorphism conditions how well sexual function recovers when androgen signaling is restored.
Why it’s in the corpus
Shows that androgen-receptor genetics determine the capacity for sexual-function recovery — a key genetic axis for explaining why some finasteride users recover and others develop persistent PFS.
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