Influence of CAG Repeat Polymorphism on the Targets of Testosterone Action
Giacomo Tirabassi; Angelo Cignarelli; Sebastio Perrini; Nicola delli Muti; Giorgio Furlani; Mariagrazia Gallo; Francesco Pallotti; Donatella Paoli
International Journal of Endocrinology2015
Summary (paraphrased)
A decade of evidence shows that the androgen receptor CAG repeat polymorphism conditions the peripheral effects of testosterone across many tissues. Longer repeat tracts blunt receptor transactivation and thereby influence male sexual function and fertility, body composition, bone metabolism, cardiovascular risk, cancer risk, psychiatric status, and neurodegenerative vulnerability. This review surveys the literature and assigns the polymorphism a central role in modulating systemic androgen action. It provides the broad physiological map against which AR-signaling disruptions in post-drug syndromes can be interpreted.
Why it’s in the corpus
Companion review to LIT-D-013: lays out the full systemic reach of AR CAG-length variation, grounding the androgen-receptor-signaling pillar of the corpus.
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