Powers gene claimCore corpus

CYP21A2; CYP21A2P — hypothesized reduced functional copies (one normal + one weak, two weak, single weak) or extra transcribed pseudogene copies

Confidence: direct (adjacent)circa 2016 (post age ~3566 days at retrieval)

Dr Will Powers’ own statements and theorizing

Paraphrased from his public posts and talks. His mechanistic and genetic claims are unpublished hypotheses — read them as “Powers theorizes…”, not as established fact.

Mentions treatments or doses — not guidance

Recorded as research context only. Nothing here is a recommendation, and some self-experiments described in sources may be dangerous. Talk to a clinician before changing anything.

Powers’ claim (paraphrased)

Some patients may carry fewer than two fully functional CYP21A2 copies, producing a subclinical adrenal-insufficiency picture: poor stress tolerance with paradoxical androgen byproduct synthesis (elevated 11-oxo-androgens on Labcorp panel) during stress. Low-dose hydrocortisone reportedly helped selected patients. Context: his trans HRT practice, not PFS.

Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.

Powers gene claim
CYP11A1 — frameshift DEL chr15:74343131 T A->T, heterozygous, rs757299093, allele frequency 1 in 15,000, ClinVar pathogenic (CYP11A1-related condition / congenital adrenal insufficiency with 46,XY sex reversal or 46,XY DSD-adrenal insufficiency)
Confidence: direct (adjacent)
A patient matching the adrenal phenotype carried this CYP11A1 frameshift (found via Nebula). Powers presented it as a non-21-hydroxylase route to the same output — anything disrupting adrenal/cortisol synthesis can produce similar effects. Context: trans HRT…
CYP11A1
PGL-CYP11A1edit, date unverifiedPFSCore corpus

Powers’ claim (paraphrased)

Powers’ claim (paraphrased)

Related records

CYP11A1 — frameshift DEL chr15:74343131 T A->T, heterozygous, rs757299093, allele frequency 1 in 15,000, ClinVar pathogenic (CYP11A1-related condition / congenital adrenal insufficiency with 46,XY sex reversal or 46,XY DSD-adrenal insufficiency)

Powers’ claim (paraphrased)

Related records

CYP11A1 — frameshift DEL chr15:74343131 T A->T, heterozygous, rs757299093, allele frequency 1 in 15,000, ClinVar pathogenic (CYP11A1-related condition / congenital adrenal insufficiency with 46,XY sex reversal or 46,XY DSD-adrenal insufficiency)