AR — upregulated expression (~1.7x, citing Khera); theorized epigenetic silencing in his phenotype
Confidence: interview/direct2026-04-29; circa May 2026
Dr Will Powers’ own statements and theorizing
Powers’ claim (paraphrased)
Citing Khera's published finding of ~1.7x AR upregulation in PFS cells, Powers theorizes intracellular weak-metabolite crowding blocks potent androgens from binding, and that in extreme cases the body epigenetically silences AR expression — producing near-zero androgenic signaling despite normal blood levels.
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Related records
- Community accountAbout Powers’ workSelf-report · N=1
PFS/PSSD: I'm going to try something interesting…
u/various (r/DrWillPowers members) · r/DrWillPowers
A patient with ~3 years of PSSD followed by PFS described Powers' theory back to the community (metabolite backlog → epigenetic androgen-receptor changes → persistent "crash") and proposed a 30-day fast as an experiment: fasting blunts the HPG axis, induces…
ARDWP-0072026PFSPSSDCore corpus - Video
Dr. Will Powers Interview [PFS / PAS / PSSD Summit 2026]
Dr. Will Powers · SIDEfxHUB - PFS & PSSD Patient Organisation · 21:27 (1287s)
PFS, PAS, PSSD mechanism theory; Powers' unifying model; vulnerability screening
ARARID1ACHD8HDAC10YT-iWFDBRTgT3g2026-04-29PFSPSSDPRSDCore corpus - Powers gene claim
ARID1A; CHD8; HDAC10 — recurring "glitches" (unspecified)
Confidence: interview
In whole-genome sequencing of ~100 PFS patients, glitches in epigenetic monitoring genes — ARID1A, CHD8, HDAC10 — appear "more than they should" statistically. Epigenetic flags (e.g., for AR upregulation) may fail to be removed after drug discontinuation.
ARARID1ACHD8HDAC10PGL-ARID1A-CHD8-HDAC102026-04-29PFSCore corpus