MTHFR — "two bad copies" (self-reported); common MTHFR SNPs (e.g., rs1801131, rs1801133) in patients
Confidence: direct (adjacent)circa 2023
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Powers’ claim (paraphrased)
Powers reported finding MTHFR mutations at high rates in his transgender patient population and in himself (two bad copies), and trialed L-methylfolate plus methylcobalamin with self-reported mental-health benefit. He hypothesized methylation defects amplify mild enzymatic sex-hormone-synthesis mutations. Context: trans/autism/ADHD comorbidity work, not PFS.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit post
Have gender dysphoria, hypermobile, ADHD or autism… / The non-AD of trans…
u/drwillpowers · r/DrWillPowers
Powers described a striking comorbidity cluster in his transgender patient population — autism, ADHD, hypermobility, POTS/dysautonomia, congenital adrenal hyperplasia, Hashimoto's thyroiditis, and GI issues — and reported discovering relevant mutations in his…
MTHFRDWP-0062023PFSPSSDCore corpus - Peer-reviewed paper
Association between MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies
Yile Wu, Xiuxiu Ding, Yehuan Sun, Huiyun Yang, Jian Chen, Xue Yan Zhao, Yuhong Jiang, Xiaoling Lv, Zhenqiang Wu · Progress in Neuro-Psychopharmacology and Biological Psychiatry
Prior studies of the MTHFR C677T polymorphism and depression had given inconclusive results, so the authors pooled 26 studies comprising 4,992 depression cases and 17,082 controls. The T allele was associated with increased depression risk overall (TT vs CC…
MTHFRMECH-0412013Systems review · Oct 2026