UGTs (glucuronosyltransferase enzymes, general) — defects (unspecified)
Confidence: direct2026-09-14
Dr Will Powers’ own statements and theorizing
Powers’ claim (paraphrased)
Defective glucuronidation was the "big break" in his PFS research: more than half of his PFS patients show ~zero androgens in urine on DUTCH testing, implicating broken glucuronidation/excretion alongside gut beta-glucuronidase disruption.
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
Related records
- Powers · Reddit post
Untitled long-form research update — new model of PFS/PSSD/post-drug syndromes (Sept 2026)
u/drwillpowers · r/DrWillPowers
Powers revised his model: the anhedonia/low-libido subtype of PFS/PSSD is driven by pathological EXCESS — not deficiency — of neurosteroids such as THDOC and androsterone that positively modulate GABA-A, causing downstream neural network remodeling…
DWP-0022026PFSPSSDCore corpus - Video
Dr. Will Powers Interview [PFS / PAS / PSSD Summit 2026]
Dr. Will Powers · SIDEfxHUB - PFS & PSSD Patient Organisation · 21:27 (1287s)
PFS, PAS, PSSD mechanism theory; Powers' unifying model; vulnerability screening
ARARID1ACHD8HDAC10YT-iWFDBRTgT3g2026-04-29PFSPSSDPRSDCore corpus - Powers · Reddit commentCurated Powers pick
Re: My doctor, William Powers, is looking for data from PSSD patients
u/drwillpowers · r/PSSD (export metadata; permalink resolves to r/DrWillPowers thread — likely crossposted)
Powers reported having seen recoveries following alteration of gut flora, and cited a PMC article (PMC6962501) for the mechanism: changing the gut microbiome changes beta-glucuronidase production, which changes how much glucuronidated hormone is de-conjugated…
UGT2B17PRH-12552026-04-13T23:48:22ZPFSPSSDPowers Reddit history