UGT2B7
UDP glucuronosyltransferase family 2 member B7
Theoretical — per Powers
Gene summary
A protein-coding gene on chromosome 4 (steroid conjugation and clearance). The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Source: NCBI Gene, accessed 2026-10-07.
Protein reference (UniProt)
- Protein
UDP-glucuronosyltransferase 2B7
- Function (excerpt)
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption.
- Subcellular location
Endoplasmic reticulum membrane.
Source: UniProtKB/Swiss-Prot P16662, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.
Why its pathway is in the library
Steroid clearance is the exit route for androgens and their metabolites — the pathway at the center of Powers' PFS model (defective glucuronidation/sulfation trapping androgens intracellularly). Gut bacterial enzymes can undo this clearance, linking it to the microbiome thread.
Written for the whole conjugation & clearance family, not for UGT2B7 specifically.
Powers’ note (his unpublished theorizing)
Named by Powers (DWP-003, unpublished) as a secondary (“minor”) glucuronidation exit whose defects can compound a UGT2B17 defect.
Narrative library record
Function
Broad-specificity glucuronosyltransferase of the UGT2B cluster that conjugates steroid hormones and many drugs for excretion; handles a wide substrate range including opioids and NSAIDs alongside endogenous steroids.
Corpus relevance
Part of the UGT2B androgen-clearance cluster Powers implicates via the DUTCH-test findings (DWP-002): if glucuronidation of androgen metabolites fails, active and weak androgens accumulate intracellularly - the metabolite backlog his model describes. Attribution: theoretical-per-Powers.
Powers’ claims naming UGT2B7
- Powers gene claim
UGT2B15; UGT2B7 — defective (minor)
Confidence: direct
Defects in these secondary glucuronidation enzymes can compound the UGT2B17 defect, further reducing testosterone exit capacity.
UGT2B15UGT2B17UGT2B7PGL-UGT2B15-UGT2B7circa May 2026PFS
Mentioned in 9 corpus records
- Powers · Reddit post
I think I have figured out at least one specific phenotype of PFS, and it is different from the "allopregnanolone" theory
u/drwillpowers · r/DrWillPowers
Powers' key genetics-first post: he proposed a specific PFS phenotype whose "base, core defect" is defective UGT2B17, disabling testosterone's main glucuronidation exit pathway. Carriers show shockingly low 3α-androstanediol glucuronide and near-zero urinary…
AKR1C1AKR1C2AKR1C3AKR1C4HSD17B2+3DWP-0032026PFSCore corpus - Powers · Reddit commentCurated Powers pick
Re: Had another random pssdpfs thought about the…
u/drwillpowers · r/DrWillPowers
Reply to a community member's glucuronidation-theory thought about sulfation labs. Powers notes the discussed factor interacts with androgen production and ABCC-family transporters (he believes ABCB1 specifically, with the caveat that he read it long ago)…
ABCB1LRP2UGT2B15UGT2B17UGT2B7PRH-13982026-04-01T15:22:34ZPFSPSSDPowers Reddit history - Powers · Reddit commentCurated Powers pick
Re: Pssd and desperate…
u/drwillpowers · r/DrWillPowers
Replying to a PSSD sufferer who theorized that TRT injections had depleted his androgens and caused penile shrinkage, Powers lays out the excess model in plain terms: the problem is too many androgens, not too few — but trapped intracellularly as accumulated…
UGT2B17UGT2B7PRH-14952026-03-28T00:28:54ZPSSDPowers Reddit history - Conference abstract
Novel mechanisms of testosterone detoxification in UGT2B17 gene deletion carriers and androgen activation by gut microbiome
Abdul Basit; John Amory; Cindy Li; Vijay Mettu; Scott Heyward; Parth B. Jariwala; Matthew R. Redinbo; Bhagwat Prasad · The FASEB Journal (Experimental Biology meeting abstract)
Proteomic comparison of human livers from UGT2B17 deletion carriers versus high expressors found upregulation of alternative steroid-metabolizing pathways (AKR1D1, AKR1C4, and related dehydrogenases/alcohol dehydrogenases) in deletion carriers, redirecting…
AKR1C4AKR1D1UGT2B17UGT2B7MECH-0142021Systems review · Oct 2026 - Gene recordPowers’ theory
AKR1C4 — aldo-keto reductase family 1 member C4
10p15-p14 (AKR1C gene cluster, chromosome 10)
3-alpha-hydroxysteroid dehydrogenase type 1; liver-restricted isoform that reduces 3-keto-5-dihydrosteroids to tetrahydro products and participates in neurosteroid synthesis. Loss of AKR1C4 alone does not cause developmental phenotypes but can worsen the…
AKR1C1AKR1C2AKR1C3AKR1C4UGT1A1+1GENE-AKR1C4Core corpus - Gene recordPowers’ theory
UGT1A1 — UDP glucuronosyltransferase family 1 member A1
chromosome 2 (2q37 region; 233.76-233.77 Mb GRCh38)
UDP-glucuronosyltransferase that conjugates glucuronic acid onto lipophilic molecules - steroids, bilirubin, hormones, drugs - converting them to water-soluble, excretable metabolites. Over 100 described variants alter its activity (for example, Gilbert…
ABCC2ABCC3UGT1A1UGT2B15UGT2B17+1GENE-UGT1A1PFSCore corpus - Gene recordPowers’ theory
UGT2B15 — UDP glucuronosyltransferase family 2 member B15
chromosome 4 (UGT2B gene cluster, 4q13 region)
Androgen-conjugating UGT expressed in liver, prostate, adipose, skin, and other tissues; glucuronidates DHT, androsterone, and androstane-3-alpha,17-beta-diol, directly terminating their activity and marking them for urinary excretion.
AKR1C2ARUGT1A1UGT2B15UGT2B17+1GENE-UGT2B15Core corpus - Gene recordPowers’ theory
Steroid-glucuronidating enzyme of extrahepatic tissues (notably prostate) that conjugates C19 steroids including DHT, androsterone, and 3-alpha-diol; notable for common copy-number variation (whole-gene deletion is frequent) associated in the literature with…
ABCC3UGT1A1UGT2B15UGT2B17UGT2B7GENE-UGT2B17PFSCore corpus - Gene recordPowers’ theory
Cytosolic sulfotransferase expressed in liver and adrenal glands that catalyzes the sulfation of steroids and bile acids, converting them into water-soluble sulfate conjugates for excretion; variants are studied for effects on circulating DHEA-sulfate levels.
HSD17B2SLCO1B1SULT2A1UGT2B15UGT2B17+1GENE-SULT2A1PFSCore corpus
Also in steroid conjugation and clearance
All 31 genes- UGT2B17Powers
UDP glucuronosyltransferase family 2 member B17
chr 4· Conjugation & clearance· 30 records - UGT2B15Powers
UDP glucuronosyltransferase family 2 member B15
chr 4· Conjugation & clearance· 13 records - AKR1C2Powers
aldo-keto reductase family 1 member C2
chr 10· Steroid synthesis· 12 records - AKR1C3Powers
aldo-keto reductase family 1 member C3
chr 10· Steroid synthesis· 9 records - AKR1C4Powers
aldo-keto reductase family 1 member C4
chr 10· Steroid synthesis· 8 records - AKR1C1Powers
aldo-keto reductase family 1 member C1
chr 10· Steroid synthesis· 7 records - SULT2A1Powers
sulfotransferase family 2A member 1
chr 19· Conjugation & clearance· 7 records - UGT1A1Powers
UDP glucuronosyltransferase family 1 member A1
chr 2· Conjugation & clearance· 7 records
Browse by family on the gene families page.