Re: Theory as to why some people so sensitive to Calcium-D-Glucarate

Powers reported that relugolix (temporary chemical castration) at least temporarily fully restores normal androgenic signaling, with patients typically noticing improvement within days — return of acne, body odor, and related signs — persisting for weeks after the trial ended, though he lacked longer-term data. He cautioned that it does not appear to correct the underlying brain miswiring caused by prolonged exposure to GABA-A positive allosteric modulating neurosteroids, and noted he ran trials until the 3α-androstanediol glucuronide (3A-ADG) fell into the normal range from values above 5,000 that maxed out the assay. He added the caveat that 3A-ADG measures only the glucuronidated metabolite, so it may not accurately reflect remaining 3α-androstanediol in serum or CSF. He framed clearing the androgen "clog" as reopening an exit pathway so the brain can drain, described the post-clearance rewiring as analogous to quitting a benzodiazepine, and said he is seeking CSF taps with mass spectrometry to identify the disrupted molecule(s) precisely — while expressing high confidence that the mechanism of both PFS and PSSD has been solved, citing the model's successful predictions (e.g., the THDOC experiment outcome and unexpected indomethacin panic reactions).