ABCC5

Source: NCBI Gene, accessed 2026-10-07.

Protein

ATP-binding cassette sub-family C member 5

Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Also acts as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity).

Subcellular location

Basolateral cell membrane; Golgi apparatus lumen; Endosome membrane; Cytoplasmic granule; Apical cell membrane.

Tissue specificity

Ubiquitously expressed, but levels in brain and muscle are especially high. All isoforms are equally expressed in retina.

Source: UniProtKB/Swiss-Prot O15440, release 2026_03, licensed CC BY 4.0. This is the protein’s normal biology, not evidence about post-drug syndromes; associated conditions are inherited disorders of the gene, not PFS, PSSD or PRSD.

Written for the whole drug transporters family, not for ABCC5 specifically.