Re: Repost dutch test results…

Reply in a thread about a community gene list for gene.iobio analysis (the export also appends some unrelated Powers replies about subreddit scope and a DUTCH repost). Powers describes three PFS phenotypes with overlap driven by each patient's specific gene glitches, and two PSSD flavors: either "PFS wearing another hat" (the SSRI caused a hormone-metabolite pileup rather than a primary neurological lesion, functioning effectively like PFS) or a variant where overactive 5HT2C suppresses dopamine despite normal dopaminergic neurons — which is why temporary overrides work but the system returns to a bad rest state. For post-Accutane syndrome he theorizes ABCC transporter glitches plus accutane's deliberate epigenetic downregulation of androgen transport, binding, and downstream transcription in skin cells: a "falling tide" that cures acne in some by lowering androgen drive, but in already-compromised patients lowers unrelated struggling cells to near zero. He also thanks the community member for their data-collection effort, expresses interest in chemical-castration volunteer outcomes for PSSD, and mentions a helpful AI tool built by his sister.