Re: The general population is so severely…
u/drwillpowers
r/tressless~3 months ago
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
On r/tressless, answering whether flushing metabolites would let the body normalize or whether damage is irreversible, Powers reports early results from the "unplug and reboot" protocol: his first patient reached female-range testosterone/DHT in about two weeks but needed nearly six weeks to clear the trapped 3a-ADG metabolite — and nobody had fully completed a reboot yet. He notes chronic low androgen signaling may cause atrophy and that epigenetic involvement is still unclear. He stresses that PFS is real but exceptionally rare, while claiming that whole-genome review of androgen-metabolism and transport genes can predict risk — illustrating susceptibility with an analogy of a drug that blinds one eye: harmless with two eyes, catastrophic with one.
Key points (paraphrased)
- First reboot-protocol data: ~2 weeks to female-range T/DHT; ~6 weeks to clear trapped 3a-ADG; no completed reboots yet.
- Atrophy risk from chronic low signaling acknowledged; epigenetic role unclear.
- PFS framed as real but exceptionally rare.
- Risk-predictability claim: WGS of androgen-metabolism/transport genes can identify susceptibility.
- "One-eyed" susceptibility analogy: the defect is silent until the system is stressed.
Why it’s in the corpus
The first reported reboot-protocol outcomes, with concrete timelines. It also captures his rarity framing and the genome-based risk-prediction claim — both important for how the corpus presents susceptibility.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who asked whether breaking the feedback loop by flushing androgen metabolites would let skin, muscles, nerves and penile tissue normalize once DHT signaling resumes, or whether the damage done is irreversible. The OP ([username removed]) had complained about misinformation downplaying finasteride's rare side effects.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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