Re: I collect more and more labsgenomedutch tests…
u/drwillpowers
r/DrWillPowers2026-04-07T23:53:27Z
Dr Will Powers’ own statements and theorizing
Mentions treatments or doses — not guidance
Summary (paraphrased)
Replying to a commenter who posted blood and DUTCH results — midrange blood testosterone with near-zero urinary androgens, no finasteride history but past ashwagandha, saw palmetto, Zoloft and Cymbalta exposure — Powers sketches informal PFS subtypes, the "brotherhoods": the UGT2B glucuronidation-defect group ("those who cannot piss out their testosterone very well") as the most textbook; the astronomical-3a-ADG group; a megalin-defect group; and an ABCC cellular-exporter group. He states that anything impairing androgen clearance beyond the normal scope creates vulnerability, and that androgenic synthesis boosters such as ashwagandha can plug the system with uncleared metabolites — leaving the system overloaded with androgens that crowd out receptor signaling so the receptors "can't hear anything."
Key points (paraphrased)
- Informal phenotype taxonomy ("brotherhoods"): UGT2B, astronomical-3a-ADG, megalin-defect, ABCC-exporter groups.
- UGT2B glucuronidation-defect group described as the most textbook presentation.
- Non-finasteride triggers (ashwagandha, saw palmetto, SSRIs) fit the same overload model.
- Receptor "crowding" image: an androgen-overloaded system where receptors cannot register the signal.
- Treatment direction hinted: clear the backlog, then "reboot."
Why it’s in the corpus
The phenotype taxonomy feeding the multi-phenotype framework. It documents non-finasteride triggers within the same model and the receptor-crowding explanation of signaling failure despite abundant androgens.
Context — the post Powers was replying toVerbatim third-party text, shown for context only — not Powers’ statement. Usernames removed.ShowHide
Powers' comment replies to [username removed], who posted blood and DUTCH results (519 ng/dL total T, near-zero urinary androgens) and asked which of several past exposures — ashwagandha, saw palmetto, Zoloft, Cymbalta, but never finasteride — could explain his symptom collection.
(Parent context recovered from the r.genit.al mirror on 2026-10-09; Powers' comment text itself is from John's user-provided export.)
Some fields on this page come from the release’s Markdown edition, which carries text the JSON edition omits.
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